This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. Last Name Huang #8. Join a growing community of 11K+ to find accountability partners, take part in productivity sprints, and join discord only events! It will provide you with confidence and methodology for demonstrating the required skills appropriately. Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Save my name, email, and website in this browser for the next time I comment. Tina has an MSc in Computer Science from the University of Pennsylvania, and an HBSc in Pharmacology from the University of Toronto. Cardiff University / Prifysgol Caerdydd. This channel is about data science, learning, and productivity. 7,794 Followers, 14 Following, 9 Posts - See Instagram photos and videos from Tina Huang (@hellotinah) hellotinah. Proc. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Green, R. E. et al. Tina Huang (@hellotinah) Instagram photos and videos Life During Adulthood: Should One Get Credit Cards? 2c). 101019659 (to K.H.). Within the pipeline, the adapters were removed by AdapterRemoval 2.2.065, reads were mapped with BWA 0.7.12 aln/samse algorithm66, duplications were removed by DeDup 0.12.1 (https://github.com/apeltzer/DeDup) and damage patterns of each library were checked with mapDamage 2.0.6 and 2.0.967. Curr. 864358 (to K.M. They, along with it, will be accessible to you indefinitely. Roebroeks, W., Mussi, M., Svoboda, J. The levels of contamination from modern human DNA were estimated on the basis of mitochondrial DNA (mtDNA), X chromosome and autosomal DNA, and with a haplotype copying model that is extended here to autosomal data in runs of homozygosity (ROH) (Methods, Supplementary Information, sections2 and 3, Supplementary Figs. At the same time, these two groups started mixing with each other, and continued to do so for around 3,000 years," Krause says. Evol. I hope you brings out more courses like these. 10 and 11). From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. PubMed Central Natl Acad. 44, W58W63 (2016). under exclusive license to Springer Nature Singapore Pte Ltd. 2022 R. Huang et al. This course is the perfect balance of teaching technical SQL concepts and optimal approaches to solving coding questions on interviews. Hi! c, MDS plot of European hunter-gatherers based on 1f3(Mbuti; pop1, pop2). She majored in mathematics before switching to computer science. Paradis, E., Claude, J. OUR UNIVERSITY Our University . Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. However, the genetic profile of contemporaneous Gravettian-associated individuals from western Europe remains unknown, as is their contribution to populations after the LGM. 35, 15471549 (2018). This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). 276, 107319 (2022). "Ice Age survivors." Philos. As a general rule of thumb, we start from the simplest issue and gradually increase in complexity. We provide a systematic description of the genomic transformations that hunter-gatherer groups experienced from the early Upper Palaeolithic onwards across western and central Eurasia and how those are possibly linked to cultural and climatic changes. In a rotator, samples were digested for at least 16h at 37C, and for pre-treated samples this was followed55 by an additional hour at 56C. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Limits of long-term selection against Neandertal introgression. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. Ontario Institute for Cancer Research Toronto, ON. 2022 Weird Science Plus - All Rights Reserved. The MDS analysis showing the genetic affinity among European hunter-gatherers was based on the distance matrix derived from outgroup f3-statistics, in the form 1f3(Mbuti.DG; pop1, pop2) and performed with classical MDS algorithm (cmdscale) implemented in R 3.5.1. Article The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. DNA was extracted from the generated bone or tooth powder following established protocols. Google Scholar. Hi, my name is Tina and I'm a data scientist at a FAANG company. 1 and 2). 2014-2020.4.01.16-0030) and C.L.S. Jensen, T. Z. T. et al. Upper Palaeolithic genomes reveal deep roots of modern Eurasians. C.L.S. The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). Floor Coatings. Jones, E. R. et al. Article de Lige, 2021). Genetics 203, 881891 (2016). This is further validated by f4-statistics of the form f4(Mbuti, Arene Candide 16; Goyet Q-2, Magdalenian-associated individuals), which is significantly positive only for El Mirn, whereas all other tested individuals and Goyet Q-2 are symmetrically related with respect to Arene Candide 16 (Supplementary Fig. Tina Huang, born on October 28, 1981, is an American stage and television actress of Taiwanese descent known for her recurring roles in Rizzoli & Isles and for her semi-regular role as Melinda Trask on the NBC soap Days of Our Lives. Le palolithique suprieur en Italie. Billed once. volume615,pages 117126 (2023)Cite this article. The competition is based on a pretty strict data set thats been collected by the Stanford Computer Science department. and H. Ringbauer developed the contamination-estimation method. In each of the past 200 years they have only seen four new entrants into their top 200 list. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. The de-multiplexed capture sequencing reads were cleaned and mapped to human reference genome hs37d5 using EAGER pipeline 1.92.5564. USA 116, 16391644 (2019). R. Soc. For ds_halfUDG libraries, we called genotypes on all targeted sites from 2bp-masked bam files; for ds_nonUDG libraries, we called genotypes on transversion sites only; for ss_nonUDG libraries, we called genotypes with single-strand mode, which ignores forward reads at C/T polymorphisms and reverse reads at G/A polymorphisms. Negative and positive controls were carried alongside each experiment. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . 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S. Shnaider received support from theRussian Science Foundation (no. 581582, 128163 (2021). 9 posts. About me. What is Marimekko Chart in Data Visualization? Evol., https://doi.org/10.1038/s41559-023-01987-0 (2023). Search 210,843,632 papers from all fields of science. Highly Influential Citations 3. The course you are purchasing is still hosted by 365 Data Science and comes with most of the perks of our dedicated platform resume builder, user dashboard, Q&A hub, and more. Int. USA 110, 22232227 (2013). I love learning new things a. Christina Yu-Ting Wang - Design Team Lead - TomTom | LinkedIn 5 Cliches About computer science flow chart You Should Avoid, What Freud Can Teach Us About brief candle in the dark my life in science. Fu, Q. et al. The horizontal dashed line marks the boundary between Late Pleistocene and Holocene. The inferred topology reveals a phylogeographic pattern irrespective of individual ages. A dynastic elite in monumental Neolithic society. . Shes the founder of Coding Black Females, a nonprofit with the aim to provide opportunities for Black female developers to develop themselves, meet familiar faces, network, receive support, and build relationships through having regular meetups., Check out the Coding Black Females website. She supports Propel on the business and marketing side. 10, 1218 (2019). 27 and 28 and Supplementary Data 3.G. Nature 615, 117126 (2023). 3b). Nature thanks Marta Mirazn Lahr, Ludovic Orlando and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). Fourth, we extend the finding of a large-scale genetic turnover as early as 14ka in central and western European hunter-gatherers associated with multiple techno-complexesFedermesser, Azilian and other Final Palaeolithic groups4despite considerable technological continuity with the preceding late Magdalenian. Danielle Fishel. My name is Tina and I'm a data scientist and YouTuber. Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). Ecol. My name is Tina and I'm a data scientist and YouTuber. 5 Summary of ROH segments detected in Eurasian hunter-gatherers. Tina Huang. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Ampliar bsqueda. Nature 536, 419424 (2016). Curr. Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. An expert in the industry, and a tireless advocate for improving it, Areej AbuAli is an inspiring person for those in the SEO space. To determine the Y-chromosome haplogroups of male individuals, we genotyped the Y-chromosome reads using a Y-SNP list (v.15.73) from the International Society of Genetic Genealogy (ISOGG) dataset, ignoring C-to-T and G-to-A transitions on the forward and reverse reads, respectively. Int. Details of the grouping and ROH segments are provided in Data S3.B. Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. My name is Tina Huang and I'm a data scientist at a FAANG company. J. Anthropol. In product development, 80% of the success of a product is determined by 20% of its features. Details of the modelling are provided in Supplementary Data 3.C. Genomic data have shown that modern humans were present in western Eurasia1,2 at least 45ka. What is Kagi Chart in Data Visualization? The dates were calibrated using OxCal 4.452 with calibration curve IntCal20 at 95.4% probability53 and when multiple dates were available for the same individual we used the function R_Combine to combine them52. In the meantime, to ensure continued support, we are displaying the site without styles However, published Gravettian-associated genomes originate from central and southern Europe, leaving the genetic profile of Gravettian-associated humangroups from western and southwestern Europe undescribed. In other words, youll never have to worry about validity issues or having to re-take the course after a certain amount of time. I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. (black) or 3s.e.m. Posth, C., Yu, H., Ghalichi, A. et al. The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. A negative and cave bear positive controls were included. Individuals at this site might mark one of the last occurrences of such high levels of hunter-gatherer-related ancestries, just centuries before the emerging European Bronze Age. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. Ancient genomes indicate population replacement in Early Neolithic Britain. Sci. Hi friends! ScienceDaily. Runtime Collective Limited (trading as Brandwatch). From around 8ka, we begin to observe admixture events with Sidelkino ancestry in central Europe. The emergence of hunter-gatherer pottery in the Urals and West Siberia: new dating and stable isotope evidence. Consultant - October 2015 to June 2016. Ecol. We applied ANGSD 0.93470 and hapCon71 for libraries from male individuals, and applied contamLD72 and a newly developed method that analyses contamination in ROH for female and male libraries (see Supplementary Information, section2 for a detailed description). The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. The science policy "Framework for Federal Scientific Integrity Policy and Practice" issued by the White House Office of Science and Technology Policy a day later is criticized as a "gag order" on scientists by PEER in an open letter (30 Jan). Nat. These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. Adapted from https://doi.org/10.5281/zenodo.5903165 (CC BY 4.0). Wood, R. E. et al. Tina Huang (@hellotinah) / Twitter Zool. 4, 11 (2007). Nature 551, 368372 (2017). You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. Lcuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. Natl Acad. Are you Tina Huang? Kristen Bell. Both of these books focus on the science and math behind data mining. ScienceDaily, 1 March 2023. Big data data warehousing and data science are two sub-tasks of a larger endeavor . Publications 4. h-index 3. In this debated framework, Gravettian-associated individuals have been suggested to represent a biologically homogeneous population on the basis of craniometric and genomic data4,22. The good news is that there are other faster engines, such as PostgreSQL, which should be faster than MySQL by quite a bit, but will take time to get running. In her journey of eventually. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. E.A. In the first place, we have traditional analysis. This suggests that the newly reported Neolithic individual from central Asia carries an ancestry that might be a good proxy for the ANE-related contribution to Iran and the Turan region45 from around 5.5ka but not to roughly contemporaneous hunter-gatherers from eastern Europe. 8). Yu, H. et al. Science 360, 548552 (2018). Now we have Areej AbuAli, an SEO manager and the founder of Women in Tech SEO. Li, H. & Durbin, R. Fast and accurate short read alignment with BurrowsWheeler transform. 4a and Supplementary Data 3.C). Every Thursday, I share insights from books, learning & productivity tips, and a coding challenge. Dolukhanov, P. in Cultural Transformations and Interactions in Eastern Europe (eds Chapman, J. For contaminated libraries we used the PMD-filtered bam files as the input for genotyping. The genetic history of Ice Age Europe. Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. (grey) of the f4 values estimated from 5cM-block jackknife analysis. Mathieson, I. et al. Science 360, eaar7711 (2018). Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. Where it all started :) I make weekly videos about self learning, practical productivity, and coding. A Free Service of Your Local Public Library and the Pennsylvania Public Libraries Film Center of the State Library of Pennsylvania Touchstone Pictures In celebration of our twentieth animated feature, we invite you to relive with us the story telling magic, the wit, the wisdom, the humor, the understanding of a very special person who gave the world a timeless and universal art form. Each bar represents one individual with the ROH grouped in four length categories (grouped by colour). Protoc. An early modern human from Romania with a recent Neanderthal ancestor. J. Archaeol. 1c and Extended Data Fig. 2. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. PubMed Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). Trzej niedwiedzi braciszkowie przeywaj swoje dziecistwo, pakujc si w najrozmaitsze tarapaty za spraw magicznego pudeka.