Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. 10. 1,2 For over 30 years, Adequan i.m. The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. 14. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. 2. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside a well-ventilated barn. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. Its expensive, but its working. Cosgrove SB, Wren JA, Cleaver DM, et al. Then reintroduce each, one by one, while monitoring for hives or other signs of allergies. Apoquel comes in tablet form only. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. To ensure that it's easy to administer the proper dosage to your dog, this treatment comes in three different dosages. These molecules are responsible for the appearance of clinical signs commonly associated with allergies, such as itching., Horses environments are full of substances that can trigger the immune system and cause allergies. Powered by Discourse, best viewed with JavaScript enabled. This content is informational/educational and is not intended to treat or diagnose any disease or patient. A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. 11. 16. Vet Dermatol 2013;24(5):479-e114. The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. 14. APQ-01043R3, halved to ensure that the ingredients are equally distributed. J Biol Chem 2007;282(28):20059-20063. One of my horses was tested at New Bolton (he has since passed away) and I was told that a serum wasnt possible or effective for most of his food-bourne allergies. Oclacitinib is well tolerated and, compared with classic allergy medications such as glucocorticoids and cyclosporine, equally effective in controlling pruritus. The Vet had put her on Apoquel as an initial dose for 10 days tapering off. Apoquel Dosage in Dogs Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Rabies in Animals. This product is top-dressed onto the feed and helps horses with equine asthma, including heaves in older horses and inflammatory airway disease in young, athletic horses.". Give one chewable per month to the dog. 18. This site is for US animal healthcare professionals. This might, down the road, be an easier and less expensive alternative for horse owners. Equine Regenerative Therapies for Managing Arthritis in Horses, Infographic | 12 Smart At-Home Biosecurity Practices for Horse Owners, Infographic | How To Keep Your Horses Joints Healthy. Panteri A, Strehlau G, Helbig R, et al. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. Apoquel For Cats: Dosage, Safety & Side Effects - Cats.com U.S. Food and Drug Administration Center for Veterinary Medicine 7500 Standish Place Rockville, MD 20855 www.fda.gov . 23. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. Speak to yourveterinarian in an emergency. Frank RK, Galvan BA, Schoell AR, et al. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Avoid storing hay in the same barn as sensitive horses. Collard WT, Hummel BD, Fielder AF, et al. Apoquel For Dogs With Allergies: Uses, Dosage and Side Effects My understanding from my vet and from what Ive read is that in horses theres been a lot of success in spacing out the dosing, but not as much success in lowering the dose amount. I hear the result have been spectacular. Apoquel is an anti-allergy drug that's often prescribed by vets. Apoquel is a prescription medication used to treat itching and inflammation in dogs. 8. So I think cost becomes dependent on that. to 14 days, and then administered once daily for maintenance therapy. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis.5 Oclacitinib is now also an effective option (BOX 1). Vet Dermatol 2017;28(5):485-e113. Thats def not nothing but its not insane. Database Record Viewer | Horse Side Vet Guide Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. In more severe cases, Apoquel can be given twice per day. This links to a pdf file Storage and Handling : Store at controlled room temperature 20 to 25C (68 . Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. Gonzales AJ, Humphrey WR, Messamore JE, et al. 17. Adv Vet Dermatol 2017;8:192-198. Its kind of cumbersome, but I have two on it, and they are doing better. Though rare, allergic reactions to medications and vaccines also occur. The most common side effect is lethargy, dry mouth, and urinary retention. Log in to fill, refill or renew the medication prescribed by your veterinarian. Dosage options starting at $0.25 per dose. The concentration of the drug is 500 mg/ml. Therefore, in many of these cases, veterinarians use steroids sparingly, says Fultz, at lower doses than recommended, or they turn to non-steroidal medications. Loft K, Simon B. Avoid storing hay in the same barn as sensitive horses, since hay particles and spores can be irritating, even from a distance and even if they are not visible in the air. Rectal Prolapse in Dogs and Cats. Fukuyama T, Ganchingco JR, Bumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. Dexamethasone: EZ Dose Micro Transdermal Gel, Dexamethasone: Twist-a-Dose Transdermal Gel, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. Apoquel | Horse and Hound Forum Search term . Allergies can develop at any time, in any horse, and seemingly for any reason. I did not know about this, but considering Im going through apoquel at a reasonable rate this sounds like it would be worth signing up for. If the diagnosis is wrong or the medication affects the horse adversely, you could endanger your horse's life. Vet Dermatol 2019;30(1):17-e6. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. Allergies can develop at any time, in any horse, and for virtually any reason. Her allergies have reared their ugly heads again - no jowl pyoderma, but ears itching. This gives you the total number of milligrams for the dose for your horse. The Feed: One of the most common recommendations for managing Equine Asthma has always been to stop feeding hay. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . Because its essentially impossible to predict these events, its important to keep records of your horses previous reactions and communicate them to your veterinarian. But Im not sure how much the long term cost will be yet. The second option is serum (blood) testing. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. Loft K, Simon B. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. Apoquel is not FDA approved to use twice daily longer than 14 days. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). 24. Cosgrove SB, Cleaver DM, King VL, et al. Most commonly, immunotherapy involves injecting gradually increasing doses of a specific allergen subcutaneously (just under the skin), explains White. Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. Use code GOODRX20 Sponsored by Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Previcox (firocoxib) | Medication: PetMD | PetMD Apoquel Side Effects: Short Term Fix, Long Term Nightmare - Vital Animal Side effects have been rarely seen and documented, but the most common occurrences have been mild vomiting and diarrhea. Owners using a nebulizer will also have to replace the medication cups on the nebulizer every few months, at a cost of about $80 per cup. Vet Dermatol This content is intended for counseling purposes only. IgE binds to cells in the body and releases inflammatory molecules. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. 7. Allergies are generally managed based on the severity of clinical signs. FREEDOM OF INFORMATION SUMMARY - Food and Drug Administration Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control. PDF HOW TO DOSE APOQUEL - Zoetis US Vet Dermatol 2016;27(Suppl 1):84 (abstract). If she suspects a product or ingredient to be the source of an allergic reaction, Fultz recommends performing elimination trials. 16. This treatment is typically effective, but the steroid is still absorbed into the body, which can result in laminitis risk, similar to Option 1. Weve been doing really well with every other day dosing. Apoquel Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. The Janus kinases (Jaks). Safety & Side Effects Apoquel is safe to use in dogs one year and older. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. Vet Dermatol 2015;26(3):171-179, e35. 3. Most common side effects are vomiting and diarrhea. Your veterinarian might also prescribe corticosteroids such as dexamethasone or prednisolone, which provide fast and effective relief from immune-mediated conditions such as allergies because of their immunosuppressive properties. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. Apoquel for dogs: Vet's guide to dosage, uses and side effects Dawn M. Cleaver, DVM - Food and Drug Administration Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. I spend $150 a month on my horse on apoquel. The steroids are usually given orally, but we may want to start with injections for a week or so in severely affected horses. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. New Approach to Equine Asthma Treatment 1800PetMeds - Shopping Cart If your horse's test results (from a BAL or tracheal wash) show a certain cell type in the lungs, we may recommend trying Zyrtec!Clenbuterol: This is a bronchodilator that may be beneficial in treating some horses with Equine Asthma. And some can got a lower dose or a further spread out dose. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea.9 A subsequent study concluded that there is no increased risk for urinary tract infections.10, The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. Ultimately, my vet did not recommend we go down that route. Stay up-to-date on the latest news about your horse's health with FREE newsletters from TheHorse.com. Topical suspension administered in the ear. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. At that point, the treatment can be changed to oclacitinib. Adding an update here in case its helpful for others. White believes that while further research in horses is warranted, veterinarians should consider latex exposure a potential risk to equine respiratory health. Apoquel For Dogs: The Best Allergy Medicine For Dogs? Dosage Chart Now divide the 10,000 mg by the 500 mg in the concentration. 25. Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. Cost is about $10 per day for the first few weeks of treatment, and may decrease to around $5 per day depending on the horses response. Apoquel delivers onset of relief within 4 hours and effectively controls itching within 24 hours. Oclacitinib was well tolerated in both studies. Dosage Chart See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Do not use Apoquel in dogs less than 12 months of age or those with serious infections. 10. Apoquel (oclacitinib) | PetMD 12. 2022 Zoetis Services LLC. Dr. Nao Hensel obtained her doctor of veterinary medicine degree from Colorado State University in 2010. Works on all common sources of allergens. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days.21 Further studies are needed to investigate adverse effects associated with long-term use in cats. 1. Urticaria (hives) is the most widely reported presentation of a skin allergy. 11. The most common side effects associated with Apoquel are vomiting, diarrhea, and lethargy. Apoquel Oclacitinib Used for Pet Meds MORE expand_more savings GoodRx lowest price $75.90 (Save -22%) local_offer Avg retail price $62.49 medication Availability Brand only Get 20% off your first order with code GOODRX20 Shop Apoquel at America's #1 Pet Pharmacy for the best pet prescription medications online! Definitely less than a horse lol but 1.5 16mg tabs a day is $$. The innovative formula of the drug allows you . Apoquel (Oclacitinib) - rrvp.com Vet Dermatol 2013;24(6):587-597, e141-142. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. Apoquel tablets are scored to be halved to ensure that the ingredients are equally distributed. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label. K. Route of Administration . 5. After remission, some dogs were well controlled with a tapered dose of oclacitinib (0.2 to 0.5 mg/kg q24h), but some needed a higher dose (0.6 to 0.7 mg/kg q12h) to avoid relapse.28,29 The exact mechanisms of oclacitinib in these diseases are unknown; however, the need for daily administration of oclacitinib indefinitely to control the disease suggests that oclacitinib plays a role in controlling the disease. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Little PR, King VL, Davis KR, et al. Proc (Bayl Univ Med Cent) 2018;31(4):524-525. RELATED CONTENT | Infographic: Equine Allergies. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982. You can use a nebulizer, an inhaler, or a single-nostril aerosol chamber. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Lucile Vigouroux holds a masters degree in Equine Performance, Health, and Welfare from Nottingham Trent University (UK) and an equine veterinary assistant certification from AAEVT. Apoquel Tablet | Free 2 Day Shipping | WalmartPetRx.com Maximizing ventilation when horses are stalled and bedding with low-dust options such as wood byproducts; Purchasing dust- or mold-free hay and wetting, soaking, or steaming it prior to feeding to reduce inhaled particles; and Offering an alternative feed than hay for low-dust options. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. Many allergic reactions are evident as a mild case of transient hives. We recommend Platinum Skin and Allergy or Aleira. It is an anti-inflammatory drug from the class of drugs known as Janus kinase (JAK) inhibitors. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. not random, very relevant and helpful! Equine Nutrition FAQ Series, sponsored by Purina Animal Nutrition. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. This is totally random but figured Id mention it since I had no idea till I saw someone mention itZoetis has a rewards program and Apoquel is one of the drugs on it. 9. Many medications are available to help manage your horses allergies, some of which are best used as preventives in sensitive horses. Pre-slaughter withdrawal time is 14 days following the last dose. Apoquel. Hives in Horses: Symptoms and Treatment - The Horse Apoquel can be administered to dogs over the age of 12 months for 14 days, during which the veterinarian would most likely decrease the dose to once a day. Once you have the horse's symptoms under control, you can try re-introducing hay. 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Excitement rather than lethargy can occur occasionally, especially in cats. Veterinarians dose Apoquel at 0.18-0.27mg per pound of bodyweight. Ortalda C, Noli C, Colombo S, et al. Vet Dermatol 2015;26(4):235-e52. Vet Dermatol 2016;27(1):22-e7. 19. These inhaled substances can trigger an allergic response that causes narrowing of the airways, mucous secretion, and cough., Luckily, minimizing common allergens in your horses environment could suffice to restore his comfort and breathing. 9. Apoquel. Avoid giving the medicine twice daily long-term. Well, one of mine is allergic to soy, corn, oats, flax and more and they were able to create just the right stuff for him. Your Price: $2.20. Long term itch reduction. Thereafter the dose should be reduced to once daily for maintenance. Providing Horses Relief During Allergy Season - The Horse It is absolutely miraculous for these itchy miserable horses. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. Derm Dialogue - Fall 2019 by TEAM - Issuu 19. Oclacitinib: Treating Pruritus and Beyond - Today's Veterinary Practice The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Atopic dermatitis is often a complex disease that requires a multifaceted approach. Apoquel For Dogs: Dosage, Side Effects, and Natural Alternatives On the label for dogs, Apoquel is used every 12 hours for the first 14 days of use, then backed down to dosing every 24 hours once a day. Apoquel for horses - Horse Care - Chronicle Forums Many allergens can cause skin reactions. Apoquel Dosing Chart For Dogs The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. There is a new drug available to help allergic horses: Apoquel. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. It is initially prescribed twice daily for 14 days, then once daily for maintenance therapy. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Dexamethasone for horses: Uses, Dosage & Side Effects - Wedgewood Pharmacy Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. Look for a supplement with at least 1,500mg of DHA per serving. The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. 6. Apoquel is the brand name of oclacitinib, a dog medication designed to relieve itching associated with allergies in dogs, particularly canine atopic dermatitis. Its important to know, however, that some horses can have BOTH types, and will need to managed year-round!What are your treatment and management options? Rosenkrantz WS, Bourgeois AS. However, the twice-daily use must not last for more than 14 days. Zyrtec: The human antihistamine may be beneficial in a small proportion of horses with Equine Asthma. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. Apoquel for Dogs: How it Works, Benefits, Dosing, and Safety Maintaining Your Horses Weight During the Winter, Special Report: Preventing 3 Common Equine Joint Issues, JACKSON- Gelding/Bay/Mustang (Nevada) - Project/Ready for Training, JENNINGS Gelding/Cremello/Mustang (BLM) Ridable (Green), recent study evaluating almost 400 potential allergens, BONNIE: Sorrel Mustang Mare Non-Riding Companion Only. KER offers EO3, which contains the omega-3 fatty acids DHA and EPA. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Fortunately, these side effects are relatively uncommon.